KIF3B mRNA表达水平与皮肤基底细胞癌病理特征的关联研究

承德医学院学报 ›› 2026, Vol. 43 ›› Issue (3): 201-205.

KIF3B mRNA表达水平与皮肤基底细胞癌病理特征的关联研究

黄欢欢, 李丹宁

河南科技大学第二附属医院病理科,河南洛阳 471000

收稿日期:2025-05-19 出版日期:2026-06-25 发布日期:2026-06-25
作者简介:黄欢欢（1986—）,女,硕士,主治医师,研究方向：皮肤基底细胞癌;E-mail：huaunghuanhuan@sina.com。
基金资助:
河南省医学科技攻关项目(LHGJ20201020127)

Study on the correlation between KIF3B mRNA and pathological features of basal cell carcinoma of the skin

HUANG Huanhuan, LI Danning

The Second Affiliated Hospital of Henan University of Science and Technology, Dept. of Pathology, Luoyang, Henan, 471000, China

Received:2025-05-19 Online:2026-06-25 Published:2026-06-25

摘要/Abstract

摘要： 目的分析驱动蛋白家族成员3B信使RNA（KIF3B mRNA）与皮肤基底细胞癌（BCC）患者病理特征的关联。方法回顾性分析河南科技大学第二附属医院2023年1月—2024年12月经病理诊断的72例BCC患者标本,以及来自门诊患者手术切除的带有正常皮肤组织的20例标本,分别列为病例组和对照组,比较2组KIF3B mRNA表达水平差异。依据病灶的病理亚型,将72例BCC患者分别列为硬化型基底细胞癌组（即侵袭性基底细胞癌组,IBCCs）和结节型及浅表型组（即非侵袭性基底细胞癌组,NIBCCs）,比较2组患者KIF3B mRNA表达水平及病理特征的差异,分析KIF3B mRNA表达水平与其病理特征间的相关性,以及对BCC的预测效能。结果病例组的KIF3B mRNA表达水平高于对照组（P<0.05）。IBCCs组的KIF3B mRNA表达水平高于NIBCCs组（P<0.05）。IBCCs组的皮损直径>1 cm占比、深部侵袭占比均高于NIBCCs组（P<0.05）。KIF3B mRNA表达水平与BCC患者的皮损直径、深部侵袭占比呈正相关（P<0.05）。KIF3B mRNA表达水平对BCC的预测灵敏度、特异度分别为89.23%、75.35%（AUC=0.866）。结论 KIF3B mRNA在BCC患者中高水平表达,其表达水平与患者病理特征密切相关,通过检测KIF3B mRNA表达水平可早期识别BCC发病风险。

关键词: 皮肤基底细胞癌, KIF3B, 病理分期, 病理特征, 预测效能

Abstract: Objective The correlation between the expression of KIF3B mRNA and the pathological characteristics of skin basal cell carcinoma. Methods Retrospective analysis of 72 specimens of BCC patients diagnosed by pathology and 20 specimens with normal skin tissue surgically removed from outpatient patients in our hospital from January 2023 to December 2024. Divide them into a case group and a control group, and the differences of KIF3B mRNA expression levels between the two groups were compared. Based on the pathological subtypes of the lesions, 72 BCC patients were classified into sclerosing basal cell carcinoma group (i.e. invasive basal cell carcinoma group, IBCCs) and nodular and superficial phenotype group (i.e. non-invasive basal cell carcinoma group, NIBCCs). The differences of KIF3B mRNA expression levels and pathological features between the two groups of patients were compared, and the correlation between KIF3B mRNA and its pathological features was analyzed, as well as its predictive power for BCC. Results The expression level of KIF3B mRNA in the case group was higher than that in the control group (P<0.05). The expression level of KIF3B mRNA in IBCCs group was higher than that in NIBCCs group (P<0.05). The proportion of lesions with diameter>1cm and the proportion of deep invasion in the IBCCs group were higher than those in the NIBCCs group (P<0.05). The expression level of KIF3B mRNA was positively correlated with the lesion diameter and the proportion of deep invasion in BCC patients (P<0.05). The sensitivity and specificity of KIF3B mRNA expression level in predicting BCC were 89.23% and 75.35%, respectively (AUC=0.866). Conclusion KIF3B mRNA is highly expressed in BCC patients, and its expression level is closely related to the pathological characteristics of BCC patients. Detection of KIF3B mRNA expression level can early identify the risk of BCC.

Key words: basal cell carcinoma of the skin, KIF3B, pathological staging, pathological features, predictive efficiency

中图分类号:

R739.5

黄欢欢, 李丹宁. KIF3B mRNA表达水平与皮肤基底细胞癌病理特征的关联研究[J]. 承德医学院学报, 2026, 43(3): 201-205.

HUANG Huanhuan, LI Danning. Study on the correlation between KIF3B mRNA and pathological features of basal cell carcinoma of the skin[J]. Journal of Chengde Medical University, 2026, 43(3): 201-205.

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https://tougao.cdmc.edu.cn/CN/Y2026/V43/I3/201

参考文献

[1] 牛昊,王佩宇,尹光文. 皮肤基底细胞癌15例临床病理分析[J]. 肿瘤基础与临床,2024,37(2):200-202.
[2] 叶婷婷,孙晓丽,王晶,等. 不同皮损表现的皮肤基底细胞癌临床误诊探析[J]. 临床误诊误治,2023,36(4):18-21,26.
[3] Hermandez LE, Mohisin N, Levin N, et al.Basal cell carcinoma: An updated review of pathogenesis and treatment options[J]. Dermatol Ther, 2022, 35(6): e15501.
[4] Durikova P.Basal cell carcinoma cytology revisited - a modern perspective on an old technique[J]. Bratisl Lek Listy, 2023, 124(10): 774-778.
[5] 吴一晨,吴飞,陈佳. 皮肤基底细胞癌发病机制及非手术治疗进展[J]. 肿瘤综合治疗电子杂志,2022,8(4):15-20.
[6] Zheng C, Li Z, Zhao C, et al.YY1 modulates the radiosensitivity of esophageal squamous cell carcinoma through KIF3B-mediated Hippo signaling pathway[J]. Cell Death Dis, 2023, 14(12): 806.
[7] 中华医学会皮肤性病学分会皮肤肿瘤研究中心,中国医师协会皮肤科医师分会皮肤肿瘤学组. 皮肤基底细胞癌诊疗专家共识(2021)[J]. 中华皮肤科杂志,2021,54(9):757-764.
[8] 屈园园,路庆丽,康晓静. 皮肤基底细胞癌238例临床与病理回顾性分析[J]. 临床皮肤科杂志,2022,51(1):24-27.
[9] Krakowski AC, Hafeez F, Westheim A, et al.Advanced basal cell carcinoma: What dermatologists need to know about diagnosis[J]. J Am Acad Dermatol, 2022, 86(6S): S1-S13.
[10] 石文丽,石巧灵,丁岩. 皮肤镜与Mohs手术治疗皮肤基底细胞癌患者的疗效观察[J]. 实用癌症杂志,2022,37(3):511-513.
[11] Abushukur Y, Ibrahim Y, Cascardo C, et al.Basal cell carcinoma with perineural invasion: a systematic review and pooled survival analysis[J]. Dermatol Surg, 2022, 48(11): 1159-1165.
[12] 王佳荣,李东霞,刘玉磊,等. 皮肤基底细胞癌的临床病理特征及其诊断[J]. 实用癌症杂志,2022,37(4):687-690.
[13] Li W, Wang W.Insights into risk factors for basal cell carcinoma: a Mendelian randomization study[J]. Clin Exp Dermatol, 2023, 48(6): 676-680.
[14] 朱阳春,陈文,崔立刚,等. 皮肤基底细胞癌、鳞状细胞癌及脂溢性角化病临床和超声特点[J]. 中国医学影像技术,2023,39(11):1698-1701.
[15] 梁键锋,冯明初,罗平平,等. 高频超声鉴别侵袭性与非侵袭性皮肤基底细胞癌的应用价值[J]. 中国中西医结合皮肤性病学杂志,2023,22(4):326-329.
[16] 黄永初,张小超,朱小美,等. 皮肤鳞状细胞癌中miR-383-5p、KIF3B mRNA的表达及临床意义[J]. 疑难病杂志,2022,21(2):162-166.
[17] 林永丽,李艳,雷东春,等. miR-383-5p与KIF3B的靶向关系及对皮肤鳞状细胞癌增殖、凋亡的调控[J]. 郑州大学学报(医学版),2020,55(2):253-257.
[18] Yao FZ, Kong DG.Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer[J]. Kaohsiung J Med Sci, 2020, 36(7): 515-522.
[19] 郑小妹,林叶飞,陈曼玲. miR-127-3p通过靶向KIF3B抑制卵巢癌细胞增殖、侵袭及迁移[J]. 现代肿瘤医学,2022,30(19):3476-3481.
[20] 张润泽,郑艳,贾惠卿,等. KIF3B基因对三阴性乳癌细胞生物学特性和阿霉素化疗敏感性的影响[J]. 青岛大学学报(医学版),2021,57(3):321-326.
[21] 赵鑫,李正霞,刘雅敏. miR-383-5p、KIF3B mRNA在皮肤鳞状细胞癌组织中的表达及其与临床病理特征的相关性[J]. 实用癌症杂志,2023,38(4):565-568.